Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives.
نویسندگان
چکیده
Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure-activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3-5), and tetrahydrozerumbone derivatives (6-9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2-9.
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ورودعنوان ژورنال:
- Biological & pharmaceutical bulletin
دوره 37 9 شماره
صفحات -
تاریخ انتشار 2014